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Additional resources for ASME Bio Process Equipment (BPE) 2005
1 General (a) Liquid filled elements in measuring devices should not contain materials that are harmful to the product. (b) Gage siphons (pigtails) should not be used. The number of isolation valves should be minimized. ). (d) Measurement elements should be designed in a way that a failure will not cause contamination hazards to the process and environment. (e) The internal volume of the instrument’s sensing element should be minimized. (f) Instruments should have integral hygienic fittings. Threaded ferrules are not acceptable to convert standard instrumentation to hygienic standards.
SD-16. 2 In-Tank Couplings (See Fig. SD-21) (a) Use of in-tank shaft couplings shall be by end user consent. (b) Use of in-tank couplings shall be restricted to locations above the liquid level. (c) In-tank couplings shall be of an acceptable hygienic design (see Fig. SD-21). (d) O-rings rather than flat gaskets should be used, if possible. 1 General (a) Agitators and mixers with their associated components shall be accessible to the cleaning fluids as specified by the end user. (b) For cleaning purposes the annular space shall have the target value of L/A ratio of 2:1 or a minimum of 1 in.
Nominal Branch Size, in. 22 ⁄4 ⁄8 1 ⁄2 3 ⁄4 3 Consideration should be given, in the design of the support, for ease of setting the correct tubing drain or slope angle. Materials of construction shall be corrosion resistant and compatible with chemical and physical performance and designed for steam service. solution to fill a circuit, and eliminate excessive piping and fittings. 10 Cross contamination of product streams shall be physically prevented. Methods of separation used in industry are: (a) removable spool piece; (b) U-bend transfer panel; (c) double block-and-bleed valve system (see Fig.